The role of p53 in cancer development

Jonathan D. Oliner
From: Science & Medicine: Volume 1 Number 4: Page 16 (October 1994)

Abstract: Few genes discovered in any field of research have achieved a level of notoriety equal to that of the p53 tumor suppressor. The reason for this is simple: p53 is more frequently mutated in human cancers than any other known gene. By examining the interactions of p53 with other cellular molecules, we are learning how p53 works and why mutating it is advantageous to tumor cells. The knowledge derived from this work may be applied to the design of novel approaches to the diagnosis and treatment of cancer.

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