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Immunoglobulin variability in systemic autoimmunity

Thomas Dorner, Peter E. Lipsky
From: Science & Medicine: Volume 9 Number 4: Page 190 (August 2003)

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Abstract: The immunoglobulin repertoire in systemic autoimmune diseases is shaped by a variety of molecular and selective influences whose effects are difficult to distinguish. The bulk of the current data indicate that there is no major genetic abnormality or errors in V(D)J recombinations in generating the B-cell receptors of SLE patients. However, abnormalities in subsequent events, such as the degree of receptor editing and somatic hypermutation as well as positive and negative selection, fundamentally alter the composition of the peripheral B-cell repertoire. Identification of the mechanisms that influence Ig V gene usage and the B-cell repertoire may allow new therapeutic strategies in these conditions.

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