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Metastasis regulatory genes

Danny R. Welch
From: Science & Medicine: Volume 9 Number 4: Page 202 (August 2003)

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Abstract: When cancer cells spread and colonize other tissues, patient survival is diminished. Yet, while millions of cancer cells migrate from primary tumors daily, only a tiny fraction of those cells successfully colonize and proliferate at secondary sites. Accumulating evidence has identified a growing number of genes that specifically control the metastatic phenotype without affecting tumorigenicity. Mutations to these genes allow migrating neoplastic cells to colonize distant loci, where the neoplastic cell then must interact with and modulate the local cellular microenvironment in order to proliferate. Discovery of metastasis suppressor genes and the context in which those genes function may allow opportunities to interfere in the metastatic cascade.

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