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Cancer metastasis to bone

John M. Chirgwin, Theresa A. Guise
From: Science & Medicine: Volume 9 Number 3: Page 140 (June 2003)

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Abstract: The frequency with which some cancers form bone metastases had previously been related to the flow of blood from affected primary organs as well as to the richly vascularized structure of trabecular bone. There, it was thought that tumor cells trapped in the capillary beds might invade the bone and destroy bone matrix directly, creating space for the tumor to grow. It is now recognized that tumors secrete factors that stimulate bone remodeling by activating bone cells, both osteoblasts and osteoclasts. Increased bone resorption releases growth factors enmeshed in the bone matrix. This creates a vicious cycle by stimulat- ing further tumor cell growth and greater activation of osteoclasts and osteoblasts.

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