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Resolution of inflammation in periodontitis

S. Dave, C. Serhan, T. Van Dyke
From: Science & Medicine: Volume 9 Number 3: Page 162 (June 2003)

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Abstract: Periodontal diseases are infectious diseases caused by predominantly gram-negative bacteria. Yet, it is becoming clear that the tissue damage that characterizes the diseases is not caused by the infectious agent directly, but by the host response. Failure of inflammation to resolve promptly may cause a large part of the tissue destruction observed, with hyperfunctional neutrophils mediating much of this damage. Endogenous prostaglandins and leukotrienes help regulate the proinflammatory response. Countering this activity is a recently discovered class of lipid-derived eicosanoids termed lipoxins that may provide immunoregulatory signals. These molecules have shown effectiveness in controlling experimental periodontal disease, and their study may offer implications in the treatment of other inflammatory diseases.

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