Science & Medicine
Home | Current Issue | Archives | Subscriptions | Contact Us

Log In | Search | Author Index | Advertising

Cancer pharmacogenomics: predicting chemotherapy response

James W. Watters, Howard L. McLeod
From: Science & Medicine: Volume 9 Number 3: Page 174 (June 2003)

View Full TextAdd To BasketPurchase Images

Abstract: Patient responses to chemotherapy are known to differ widely across patient populations. Pharmacogenomics, or the study of genetic differences underlying interindividual variability in drug responses, seeks to identify genetic polymorphisms in drug-metabolizing enzymes and other molecules influencing drug activity. The goal is to individualize the selection of chemotherapy agents and dosages prospectively for each patient in order to optimize the likelihood of treatment success and to avoid the severe systemic toxicity that is a hallmark of chemotherapy. Microarray analyses and mouse models are valuable tools enabling genome-wide searches for candidate genes and polymorphisms.

Back to Table of Contents



Science & Medicine, Inc.
P.O. Box 313, Narberth, PA 19072
(610) 660-8097       (800) 888-0028
fax (610) 660-0348
e-mail editor@sciandmed.com
See our other journal: Medical Problems of Performing Artists.
Home | Current Issue | Archives | Subscriptions | Contact Us

Log In | Search | Author Index | Advertising

Copyright © 2002-2019, Science & Medicine, Inc.

Powered by Pliner Solutions, Inc.
Web Development by Pliner Solutions, Inc.