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Parkinson's disease: part 3. Surgical and emerging therapies

Christopher Janson, Paola Leone, Andrew Freese
From: Science & Medicine: Volume 9 Number 2: Page 82 (April 2003)

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Abstract: For the past 50 years, enthusiasm has remained high that parkinsonism is a treatable disorder, whether by surgical or medical means. The development of varied surgical approaches over the years have proved only partially successful in palliating the common symptoms and motor complications of Parkinson's disease, yet these efforts helped to highlight the basal ganglia as the primary region of disease pathology. Surgery targeting the basal ganglia remains highly successful in reducing motor deficits in patients. Deep brain stimulation targets the same regions using high-frequency electrical impulses to control tremor. Newer emerging treatments, such as gene therapy and restorative cell approaches, seek to correct dopamine deficits and to restore diseased neurons.

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