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Targeting the endothelium in sepsis and multiorgan dysfunction

William C. Aird
From: Science & Medicine: Volume 9 Number 2: Page 108 (April 2003)

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Abstract: Most basic studies of sepsis pathophysiology have focused on specific, individual mechanisms of the host response. Those investigations arise from an idea that the components of the host response form a sequential cascade, what might be called a linear model of pathophysiology. Their results tend to reinforce that notion, so that therapeutic trials are based on attenuating a single component in the cascade. The disappointing results of single-target trials point to the need for a conceptual shift away from a linear model and toward a more expansive set of spatial and temporal networks in which endothelium is key.

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