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Resolution of pulmonary edema

Michael A. Matthay
From: Science & Medicine: Volume 9 Number 1: Page 12 (February 2003)

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Abstract: Patients with acute lung injury or ARDS who have impaired epithelial fluid clearance show poorer outcomes than patients with intact fluid clearance. From in vivo studies in sheep done 20 years ago, it was suggested that clearance of alveolar fluid involves active ion transport. Subsequent studies confirmed that active sodium transporters expressed in the alveolar epithelium are primarily responsible for fluid removal from the lung during disease or injury. Upregulating alveolar Na+ transporters and Na+,K+-ATPases increases fluid resorption and may be achieved with b-adrenergics or by catecholamine-independent methods, offering therapeutic possibilities.

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