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Parkinson's disease: part 2. Cellular basis of medical treatment

Christopher Janson, Paola Leone, Andrew Freese
From: Science & Medicine: Volume 9 Number 1: Page 24 (February 2003)

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Abstract: Parkinson's disease has a variety of medical treatment options, most of which act on the dopaminergic systems of the basal ganglia. Especially under conditions of denervation, the physiology of basal ganglia neurotransmission is complex, and no single agent is sufficient to address all the motor, cognitive, and autonomic symptoms. For this reason, emerging treatments, such as neuroprotective drugs, restorative cell and gene-based approaches, and surgical options, remain an essential complement to polypharmacy with the existing drugs.

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