Science & Medicine
Home | Current Issue | Archives | Subscriptions | Contact Us

Log In | Search | Author Index | Advertising

Vascular mechanisms in preeclampsia

Raouf A. Khalil
From: Science & Medicine: Volume 9 Number 1: Page 36 (February 2003)

View Full TextAdd To BasketPurchase Images

Abstract: Preeclampsia involves severe increases in vascular resistance and arterial pressure, but the vascular mechanisms remain unclear. A reduction in uteroplacental perfusion pressure and the ensuing placental ischemia trigger the release of placental factors such as cytokines and reactive oxygen species, leading to endothelial cell dysfunction and a reduction in endothelium-dependent vascular relaxation. Placental factors also may increase the release of endothelium-derived contracting factors, such as endothelin-1, thromboxane, and angiotensin II. These contracting factors may increase intracellular Ca2+ and stimulate Ca2+-dependent contraction pathways or increase the activity of specific protein kinases, increase myofilament force sensitivity to intracellular Ca2+ and enhancing vascular smooth muscle contraction.

Back to Table of Contents



Science & Medicine, Inc.
P.O. Box 313, Narberth, PA 19072
(610) 660-8097       (800) 888-0028
fax (610) 660-0348
e-mail editor@sciandmed.com
See our other journal: Medical Problems of Performing Artists.
Home | Current Issue | Archives | Subscriptions | Contact Us

Log In | Search | Author Index | Advertising

Copyright © 2002-2019, Science & Medicine, Inc.

Powered by Pliner Solutions, Inc.
Web Development by Pliner Solutions, Inc.