Science & Medicine
Home | Current Issue | Archives | Subscriptions | Contact Us

Log In | Search | Author Index | Advertising

TGF-beta, smads, and tissue fibrosis

John Varga
From: Science & Medicine: Volume 8 Number 6: Page 298 (February 2002)

View Full TextAdd To BasketPurchase Images

Abstract: A cytokine with many functions, TGF-b is central to the process of wound healing. Dysregulation of that process results in fibrosis, but interventions that reduce TGF-b activity are likely to have adverse effects on unrelated TGF-b functions. Other approaches would be made possible by understanding how TGF-b signals reach the nucleus and how consequent extracellular matrix formation is normally brought to a halt. Recent work has disclosed a previously unknown family of second messengers known as Smads. Investigations in cultured cells and animal models have provided a concept of how these proteins stimulate or suppress gene transcription.

Back to Table of Contents



Science & Medicine, Inc.
P.O. Box 313, Narberth, PA 19072
(610) 660-8097       (800) 888-0028
fax (610) 660-0348
e-mail editor@sciandmed.com
See our other journal: Medical Problems of Performing Artists.
Home | Current Issue | Archives | Subscriptions | Contact Us

Log In | Search | Author Index | Advertising

Copyright © 2002-2020, Science & Medicine, Inc.

Powered by Pliner Solutions, Inc.
Web Development by Pliner Solutions, Inc.