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Homeostatic regulation by hypoxia-inducible factor 1

Gregg L. Semenza
From: Science & Medicine: Volume 8 Number 6: Page 338 (February 2002)

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Abstract: Hypoxia-inducible factor 1 (HIF-1) was originally identified in the nuclei of mammalian cells, where it accumulated in response to hypoxia and bound to the EPO gene hypoxia-response element. HIF-1's DNA-binding activity was tightly regulated by O2 tension. It has since been found that HIF-1 plays an important role in O2 homeostasis by activat-ing transcription of genes whose products mediate essential cellular and systemic responses to hypoxia, including erythropoiesis, glycolysis, vasculogenesis, and vasodilation. HIF-1 represents an important link between O2 sensing, gene transcription, and physiologic adaption to acute and chronic hypoxia in vivo.

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