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Reversing hepatic fibrosis

Scott L. Friedman, Michael J.P. Arthur
From: Science & Medicine: Volume 8 Number 4: Page 194 (August 2002)

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Abstract: For years, hepatic fibrosis has been viewed as a condition leading to cirrhosis and eventual death. In the last two decades, research has begun to reveal the mechanisms underlying fibrosis. Hepatic stellate cells have been identified as the key fibrogenic cells in the liver, and signals from these cells drive the formation of extracellular matrix as well as its degradation. It has also been found that even advanced fibrosis and cirrhosis may be reversible with treatment. Improved knowledge of the mechanisms underlying hepatic fibrosis provide a framework to identify sites of potential antifibrotic therapy.

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