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Molecular regulation of muscle wasting

Per-Olof Hasselgren
From: Science & Medicine: Volume 8 Number 4: Page 230 (August 2002)

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Abstract: Muscle wasting is a common finding in sepsis and severe injury, as well as in many chronic diseases. New research into the molecular biology of this condition has established that wasting is due to muscle protein breakdown, in particular the breakdown of the myofibrillar proteins actin and myosin, which is accomplished largely by the ubiquitin-proteasome proteolytic pathway. For muscle cachexia to develop and for protein degradation to be complete, other mechanisms also become involved at points before, during, and after proteasomal degradation. Understanding the molecular regulation of muscle wasting should suggest possible therapeutic strategies that intervene at particular steps in the wasting process.

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