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Tissue renin-angiotensin systems

Michael Bader
From: Science & Medicine: Volume 8 Number 3: Page 128 (June 2002)

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Abstract: The renin-angiotensin system is a major physiologic regulator of blood pressure and blood volume. On the other hand, it is also responsible for hypertrophic and fibrotic damage to the cardiovascular organs that results from hypertension and diabetes. Angiotensin II, the effector peptide in the system, is generated not only in the circulation but also locally in the kidney, heart, brain, and adrenal gland. These local renin-angiotensin systems may be more important pathophysiologically than the systemic one.

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