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Breast cancer susceptibility genes

Thomas G. Boyer, Wen-Hwa Lee
From: Science & Medicine: Volume 8 Number 3: Page 138 (June 2002)

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Abstract: The last decade of the 20th century witnessed the identification and initial characterization of two major breast cancer susceptibility genes, BRCA-1 and BRCA-2. Studies of the encoded BRCA proteins have revealed roles in the maintenance of chromosomal stability and in DNA damage response and repair, and studies continue to illuminate further biological activities. A greater appreciation of the involvement of BRCA-1 and 2 in breast and ovary cells will increase the probability that recent advances in our understanding of their biological functions will be channeled effectively to the treatment and prevention of breast and ovarian cancer.

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