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Treating psoriasis with biologic agents

James G. Krueger
From: Science & Medicine: Volume 8 Number 3: Page 150 (June 2002)

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Abstract: Epidermal hyperplasia and vascular changes that characterize psoriasis result from chronic inflammation within the skin that is mediated by activated T cells. Sequential activation of Langerhans cells and naive T cells generates memory T cell subsets that home specifically to inflamed skin. After exiting cutaneous postcapillary venules, differentiated type 1 T cells cause inflammation by activating cytokine and chemokine pathways. A number of biologic agents designed to block particular cell interactions in the cutaneous immune response are being tested in psoriasis.

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