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Natural killer cells in bone marrow transplantation

William J. Murphy
From: Science & Medicine: Volume 8 Number 3: Page 162 (June 2002)

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Abstract: Natural killer cells mediate the MHC-unrestricted killing of transformed and virally infected cells as part of the innate immune system. In bone marrow transplantation, they also are involved in mediating graft rejection and in the beneficial graft-vs-tumor effect. Recently, activating and inhibitory receptors have been identified on NK cells, which help explain how NK cells recognize and attack particular cells. By selecting NK cells with specific receptors, it may be possible to improve graft survival in HLA-mismatched transplants as well as to tailor immuno-therapy to overcome tumor evasion.

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