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Immunophilin ligands in nerve regeneration

Bruce G. Gold
From: Science & Medicine: Volume 8 Number 2: Page 66 (April 2002)

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Abstract: Immunophilins are a family of proteins so named because they serve as receptors for the immunosuppressant drugs cyclosporin A and FK506. While initially found in immune cells, immunophilins are also abundant in neurons, where they participate in a variety of functions including protein folding and trafficking. There, inhibition of these receptors using immunophilin ligands has shown neuroprotective and neuroregenerative effects in models of Parkinson's disease, stroke, and other neuropathies. Derivatives of these agents that lack the immunosuppressant effects are entering clinical trials and may hold potential uses in treating neurologic disorders.

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