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Primary pulmonary hypertension

Mitchell D. Botney
From: Science & Medicine: Volume 8 Number 1: Page 8 (February 2002)

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Abstract: High blood pressure in the pulmonary circulation is a consequence of structural and functional changes, most commonly the result of hypoxia from lung disease or
high blood flow from a cardiac shunt. Much less common is pulmonary hypertension arising within the pulmonary arteries themselves, not associated with any
disorder that can bring about secondary pulmonary hypertension. Endothelial cell injury from any of several causes, coupled with hemodynamic changes that follow the initial response of the vessel wall to the injury, is thought to initiate a process of structural remodeling that is different from what is seen in systemic arteries subjected to similar insults.

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