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Sodium-hydrogen exchange in heart disease

Morris Karmazyn
From: Science & Medicine: Volume 8 Number 1: Page 18 (February 2002)

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Abstract: Intracellular acidosis induced by myocardial ischemia activates pH regulatory systems, including the sodium-hydrogen exchanger. During ischemia and reperfusion, Na-H exchange indirectly elevates calcium levels, resulting in cardiac cell injury. Na-H exchange also appears to be involved in the chronic response of myocardial cells to ischemia, particularly the remodeling process. Though much remains to be done with regard to understanding how the exchanger is regulated, inhibitors of this transporter offer promise as effective agents to treat acute as well as chronic responses after myocardial infarction.

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