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Cardiovascular steroidogenesis

Simon H. Slight
From: Science & Medicine: Volume 8 Number 1: Page 36 (February 2002)

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Abstract: Steroids with mineralocorticoid and glucocorticoid activities are essential to life. Aldosterone, the principal mineralocorticoid, and cortisol, the major glucocorticoid in humans, are synthesized in the adrenal cortex, which until recently was believed to be their only source. Recent studies show that cardiovascular tissue also expresses genes necessary for steroidogenesis, and that the heart and blood vessels elaborate both aldosterone and corticosterone. It is likely that steroids thus formed remain within their tissue of origin and have local actions, which might include modulating tissue structure and regulating vascular tone.

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