Science & Medicine
Home | Current Issue | Archives | Subscriptions | Contact Us

Log In | Search | Author Index | Advertising

Pathogenesis of diabetic neuropathy

Sheldon Chen, Alberto Casaretto, Fuad N. Ziyadeh
From: Science & Medicine: Volume 7 Number 1: Page 10 (February 2000)

View Full TextAdd To BasketPurchase Images

Abstract: Increases in blood pressure, first within glomerular capillaries and later systemically, and the metabolic consequences of abnormally high glucose levels in renal cells are the components of the most widely accepted concept of how diabetic nephropathy develops and progresses. Both abnormalities induce a maladaptive response in which TGF-beta is over-produced and in turn stimulates excessive synthesis of extracellular matrix molecules. Expansion of the glomerular mesangium and tubulointerstitial fibrosis, which are the pathological characteristics of diabetic nephropathy, result from an accumulation of excess extracellular matrix.

Back to Table of Contents



Science & Medicine, Inc.
P.O. Box 313, Narberth, PA 19072
(610) 660-8097       (800) 888-0028
fax (610) 660-0348
e-mail editor@sciandmed.com
See our other journal: Medical Problems of Performing Artists.
Home | Current Issue | Archives | Subscriptions | Contact Us

Log In | Search | Author Index | Advertising

Copyright © 2002-2019, Science & Medicine, Inc.

Powered by Pliner Solutions, Inc.
Web Development by Pliner Solutions, Inc.