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DNA vaccines

Maria L. Oyaski, Hildegund C.J. Ertl
From: Science & Medicine: Volume 7 Number 1: Page 30 (February 2000)

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Abstract: Vaccines are one of western medicine's greatest contributions to human health. Decades of experience with traditional vaccines, combined with advances in understanding the immune system, point to possibilities for improvement in the areas of safety, efficacy, cost, and delivery. Using naked DNA as a vaccine, so that the immunogen is synthesized by host cells, is one of several new methods. Extensive testing in animal models has indicated that DNA vaccines are safe, inexpensive, and able to mimic the full spectrum and duration of immune responses induced by natural infection.

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