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Signal transduction pathways in caveolae

Rennolds S. Ostrom, Paul A. Insel
From: Science & Medicine: Volume 7 Number 1: Page 44 (February 2000)

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Abstract: Components involved in signal transduction by G protein-coupled receptors and teceptor tyrosine kinases are now known to exist primarily, and in many cases exclusively, in specific microdomains of the plasma membrane called caveolae. Caveolar microdomains appear to be preferential sites for cellular activation by a wide variety of hormones and growht factors, and they may prove to be sites altered in desease states associated with dysregulated signaling, including cancer, as well as routes for intoxication and infection by certain bacteria and other microorganisms.

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