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Radiation-induced effects in unirradiated cells

Rashi Iyer, Bruce E. Lehnert
From: Science & Medicine: Volume 7 Number 1: Page 54 (February 2000)

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Abstract: The cell's nucleus and particularly its DNA obviously are important targets for the cell killing, mutagenic, and oncogenic effects of ionizing radiation. Even so, it is now clear that many of these same effects can occur when extranuclear compartments of the cell are irradiated. In vitro, some of the effects can be induced through bystander mechanisms even in cells that are not directly exposed to radiation. Some but certainly not all evidence implicates reactive oxygen species as a principal and potentially unifying mechanistic component.

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