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IgE and its receptor as therapeutic targets

Sarbjit S. Saini, Bruce S. Bochner
From: Science & Medicine: Volume 6 Number 6: Page 28 (December 1999)

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Abstract: No matter what specific allergen is the trigger, the allergic response in an stopic person involves binding of allergen to IgE complexed with high-affinity IgE receptors on mast cells and basophils. A potential new intervention emplays anti-IgE monoclonal antibodies that block IgE receptor bindings. Studies with these antibodies have exposed a link between free IgE levels and IgE receptor expression on basophils and uncovered a regulatory loop that has implications beyond the therapeutic use of the antibody.

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