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Quorum sensing and virulence in Pseudomonas

Teresa R. de Kievit, Barbara H. Iglewski
From: Science & Medicine: Volume 6 Number 6: Page 42 (December 1999)

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Abstract: Cell-to-cell signaling enables P. aeruginosa to "sense" its environment and to control expression of many of its toxic prducts in response to cell density. During infection, repression of virulence factor production at low cell densities may be a means of ensuring that a sufficient bacterial population can be amassed to overwhelm the host before an immune response is mounted. Biofilm production, an area of considerable concern in the clinical setting, has also been linked to quorum sensing. Other bacteria are being found to use similar signaling systems, so strategies designed to disrupt quorum sensing in P. aeruginosa may have broad antimicrobial applicability.

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