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Radiation therapy in xenotransplantation

Edward C. Halperin
From: Science & Medicine: Volume 6 Number 6: Page 52 (December 1999)

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Abstract: External beam irradiation prior to or after transplantation was part of many transplant regimens at one time, and total lymphoid irradiation is an effective therapy for Hodgkin's disease. In small-scale animal studies of xenotransplantation, lymphoid irradiation combined with other immunosupperessive therapies has tended to prolong graft survival, thaugh the effect is clearest when the two animal species are closely related. Radiation alone cannot overcome hyperacute rejection caused by the activation of complement, but it may diminish acute or chronic rejection that occurs when cellular and humoral immune responses to the graft are elicited in its recipient.

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