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Myocardial preconditioning

Ryan M. Fryer, Garrett J. Gross
From: Science & Medicine: Volume 6 Number 5: Page 28 (October 1999)

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Abstract: In experimental animals and in cultured human tissue, intermittent periods of ischemia have been found to precondition the heart so that it is less affected by a subsequent episode of prolonged ischemia. In patients, an attack of angina shortly before an acute myocardial infarction may induce a similar response. Patients undergoing multiple balloon inflations during angioplast procedures also seem to benefit from a cardioprotective effect. Efforts to take clinical advantage of this phenomenon are focused on establishing its mechanism and on devising a drug that can reproduce the effect of the ischemic episode.

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