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Myocyte dysfunction in heart failure

Edward G. Lakatta, Steven R. Houser
From: Science & Medicine: Volume 6 Number 4: Page 8 (August 1999)

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Abstract: Disturbances in intracellular calcium ion flux appear to underlie the progressive myocyte dysfunction that characterizes heart failure. Many questions remain to be answered about how calcium handling becomes dysregulated and about the subsequent sequence of events, but recent studies of gene expression levels in normal and stressed cardiac muscle have begun to suggest some answers. Increased levels of the sarcolemmal Na+-Ca++ exchanger point to a role for this membrane associated molecule in the adaptive response ot the steress factors that are common to all dilated cardiomyopathies.

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