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Systemic lupus erythematosus

Daniel J. Wallace
From: Science & Medicine: Volume 6 Number 4: Page 18 (August 1999)

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Abstract: Lupus is a complex autoimmune disease in which every phase of the interaction between antigen-presenting cells, T cells, and B cells is dysregulated. Because macrophage function is disturbed, remnants of cells that have undergone apoptosis are inefficiently cleared. B cells produce antibodies to these circulating autoantigens, and the resulting immune complexes of various charges and sizes are also poorly cleared by the reticuloendothelial system. Deposited in tissues, they induce further inflammatory damage. Considering the variety of specific dysfunctions in lupus, it is possible that replacement of the immunologic environment by gene therapy or stem cell transplantation will be necessary for effective treatment.

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