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Modifiers of the estrogen response

Jeffrey W. Pollard
From: Science & Medicine: Volume 6 Number 4: Page 38 (August 1999)

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Abstract: In the traditional view, estrogen induces the expression of target genes whose protein products whose protein products are responsible for the hormone's effects. That simple scheme is only part of the story, for estrogen receptors can be activated in the absence of hormone, and the hormone-receptor complex can act as an integrator of signals from other sources. Adding to the complexity of the extrogen response is the recent realization that genes not yet identified can alter estrogen responsiveness in laboratory animals, and presumably in humans as well. The differential effects of estrogens in different tissues and between individuals may ultimately be explained when the genetically determined influences are understood.

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