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Angiogenesis

Patricia A. D'Amore, Yin Shan Ng, Diane C. Darland
From: Science & Medicine: Volume 6 Number 3: Page 44 (June 1999)

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Abstract: The early vascular plexus in the embryo forms by assembly of endothelial cell precursors of angioblasts in the process termed vasculogenesis. New capillaries may also arise by sprouting form existing vessels, innthe process known as angiogenesis. Cells recruited from the surrounding mesenchyme differentiate to pericytes along capillaries or to smooth amuxcle cells along larger vessels. Some of the factors involved in angiogenesis have been identified, and the process is partly recapitulated in disorders characterized by neovascularization, including diabetic retinopathy and tumor vascularization. Studies of cell cultures and the use of animal models are revealing the molecular mechanisms of angiogenesis and providing potential method for treating these disorders.

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