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Post-polio syndrome

Marinos C. Dalakas
From: Science & Medicine: Volume 6 Number 3: Page 54 (June 1999)

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Abstract: Between 10% and 50% of survivors of acute paralytic poliomyelitis develop new neuromuscular symptoms after decades of clinical stability. The post-polio syndrome is a clinical diagnosis, but on the basis of laboratory findings in some patients, three explanations for it have been proposed. First, new weakness may result from the death of motor neurons that have been overstressed while compensating for the loss of neurons destroyed during the acute attack. Second, there may be an ongoing imminopathological mechanism. And third, although polio-viruses kill cells by apoptosis in virto, they may persist in some form in neurons, which ordinarily are resistant to apoptosis.

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