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Metabotropic glutamate receptors

P. Jeffrey Conn
From: Science & Medicine: Volume 6 Number 1: Page 28 (February 1999)

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Abstract: Clinical trials have begun of the first experimental drug that targets a member of a specialized family of receptors in the brain. Different subtypes of metabotropic glutamate receptors are found in defferent brain regions, and the receptors appear to function as regulators of synaptic transmission . The expectation is that selective agonists and antagonists will be useful in neurologic and psychiatric disorders affecting particular neural networks or brain regions without altering the generalized excitatory role of glutamate acting through its ionotropic receptors. Theoretically at least, a wide reange of diseases might be amenable to treatment by agents targeted at metabotropic glutamate receptors.

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