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Searching for prostate cancer genes

John D. Carpten, Jeffrey R. Smith, Dietrich A. Stephan, Jeffrey M. Trent
From: Science & Medicine: Volume 5 Number 6: Page 26 (December 1998)

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Abstract: Prostate cancer is the second most common malignancy in U.S. men. Estimates are that perhaps 10% of prostate cancers are ingerited. As is true for breast and colon cancer, the inherited cancers occur earlier and are more aggressive. Efforts to implicate tumor suppressor genes and to investigate both duplications and losses of DNa sequences in families with prostate cancer have not identified a susceptibility locus. A genome-wide search, however, has provided evidence for such a locus on chromosome 1. If detailed maps of the region turn up a predisposing gene, then understanding its function should help explain sporadic as well aas hereditary forms of prostate cancer.

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