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Squamous cell carcinoma

Norbert M. Wikonkal, Douglas E. Brash
From: Science & Medicine: Volume 5 Number 5: Page 18 (October 1998)

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Abstract: Ultraviolet light absorbed by DNA molecules in keratinocytes is the inciting cause of squamous cell carcinoma of the skin. Failure of DNA repair enzymes to correct thee UV-induced damage can lead to mutations when cells divide. Particular mutations in the tumor suppressor gene p53 are characteristic of UV damage and are commonly found in squamous cell carcinoma. If these mutations result in production of defective p53, the protein's functions in cell cycle control and facilitating apoptosis will be absent, allowing clonal expansion and eventual cancer. The visibility and accessibility of squamous cell carcinoma of the skin have made this tumor one of the best understood human malignancies.

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