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Anti-Gal antibody prevents xenotransplantation

Uri Galili
From: Science & Medicine: Volume 5 Number 5: Page 28 (October 1998)

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Abstract: More than 80% of patients in need of a heart, kidney,, or liver allograft fail to receive the needed organ because of an insufficient number of organ donors. Extensive research is being conducted on the use of pig xenografts as alternatives to allografts. Such xenografts are rejected in humans and in monkeys, primarily by interaction of the natural anti-Gal antibody with alpha-gal epitopes on pig cells. Prevention og this interaction is a prerequisite for progress in xenotransplantation. The immunologic potential of anti-Gal may be exploited, however, for clinical uses such ass the improvement of the effeicacy of autologous cancer vaccines.

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