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Chlamydial resistance to host defense

Guangming Zhong, Robert C. Brunham
From: Science & Medicine: Volume 5 Number 5: Page 38 (October 1998)

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Abstract: Able to multiply only within cells, chlamydiae have evolved a strategy for maintaining the integgrity of the host cells they invade. Other intracellular pathogens induce infected cells to undergo apoptosis, but chlamydiae obtain energy as well as nutrients from host cells and must therefore preserve host cell mitochondrial function long enough to produce infections progeny. The molecular mechanisms of apoptosis itself are not yet completely understood. Determining how chlamydiae inhibit apoptosis could illuminate the multiple pahtways by which data signals are transduced to effect cells suicide.

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