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Mechanisms of tumor suppressor genes

Lief W. Ellison, Daniel A. Haber
From: Science & Medicine: Volume 5 Number 4: Page 26 (August 1998)

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Abstract: People who have inherited a predisposition to cancer most often have mutations in henes that encode tumor suppressor proteins, loss of whose function is critical to the initiation of tumor development. The best characterized tumor suppressors ste involved in the control of cell proliferation, as might be expected. But as the list of tumor suppressor genes grows longer, the range of their apparent functions becomes more diverse. Keys to understanding the significance of tumor suppressor gene mutations are the cell type specificity of most of them and the genetic pathways in which they function.

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