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Molecular mechanisms of general anesthetic action

Neil L. Harrison, Pamela Flood
From: Science & Medicine: Volume 5 Number 3: Page 18 (June 1998)

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Abstract: Multiple effects on the central nervous system that are produced by general anesthetic agents seem likely to be mediated by receptor molecules residing in neuronal membranes. In some instances, specific mechanisms have been worked out. The obscure pharmaco-dynamics of other agents are yielding to powerful neurobiological techniques, nd studies in transgenic mice are getting underway. Future anesthetics may be designed and synthesized to act at known targets, in the hope of diminighing the likelihood of side effects and further enhancing the contributions of anesthesia to clinical medicine.

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