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T cell recognition of glycosylated peptides

Tim Elliott
From: Science & Medicine: Volume 5 Number 3: Page 44 (June 1998)

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Abstract: T cell receptors recognize antigen agter the foreign or mutant protein has been processed within an infected cell. A fragment of the antigenic molecule, called an epitope, is presented at the cell surface by a class I or class II MHC molecule, and the T cell receptor must be in contact with both the epitope and the HC molecule in order for recognition to occur. Attachment of a sugar unit to a peptide epitope can interfere with T cell recognition. Experimentally, it is also true that some T cell responses depend upon the presentation of glycosylated peptides by MHC molecules.

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