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Contrast-enhanced ultrasound imaging

Flemming Forsberg, Barry B. Goldberg
From: Science & Medicine: Volume 5 Number 3: Page 54 (June 1998)

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Abstract: Air conducts sound ineffectively, and ultrasound waves scarcely at all. Therefore, injected microbubbles are useful in improving the reflected signal intensity from flowing blood. Ultrasound contrast agents already on the markey are composed of bubbles small enough to traverse capillaries and durable enough to endure several cardiac cycles. they appear to increase the sensitivity of Doppler ultrasound to the degree that slowly flowing blood can be delineated within the toruous small vessels typical of malignant tumors. Microbubbles resonate when struck b an incident ultrasound pulse, so that harmonic and subharmonic frequencies are reflected along with the incident frequency. Targeting ultrasound agents to specific tissues an loading them with drugs or DNA are under investigation.

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