Science & Medicine
Home | Current Issue | Archives | Subscriptions | Contact Us

Log In | Search | Author Index | Advertising

Experimental models of Alzheimer's disease

Mark P. Mattson
From: Science & Medicine: Volume 5 Number 2: Page 16 (April 1998)

View Full TextAdd To BasketPurchase Images

Abstract: The power of molecular genetics lies in its ability to first identify gene defects and then, by introducing these defects into cultured cells and animals, to elucidate the molecular mischief responsible for cell dysfunction and death. In Alzheimer's disease research, the molecular approach has revealed the cellular alterations that result in age-related degeneration of neurons in the brain. Mutations that result in increased levels of oxidative stress and disruption of calcium regulation in neurons may accelerate changes that occur during usual aging. Experiments in cell cultures and animal models of Alzheimer's disease have identified a variety of agents that can promote survival of neurons, even in the face of mutations.

Back to Table of Contents



Science & Medicine, Inc.
P.O. Box 313, Narberth, PA 19072
(610) 660-8097       (800) 888-0028
fax (610) 660-0348
e-mail editor@sciandmed.com
See our other journal: Medical Problems of Performing Artists.
Home | Current Issue | Archives | Subscriptions | Contact Us

Log In | Search | Author Index | Advertising

Copyright © 2002-2019, Science & Medicine, Inc.

Powered by Pliner Solutions, Inc.
Web Development by Pliner Solutions, Inc.