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Ribozymes

Helen A. James, Ian Gibson
From: Science & Medicine: Volume 5 Number 2: Page 26 (April 1998)

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Abstract: Demonstrating that RNA molecules can act as enzymes was rewarded by a Nobel Prize in chemistry in 1989, at about the same time that the requirements for constructing synthetic RNA catalysts were developed and published. In spite of their evident therapeutic potential against viral RNA's or deleterious gene transcripts, ribozymes have been slow to move from experimental cell-free systems to cell lines or animal models. Difficulties include instability of the synthesized molecules in the presence of nucleases and accessibility to RNA whose three-dimenstional structure is not known.

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