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Dynamics of HIV infection

------A Special Report---------
From: Science & Medicine: Volume 5 Number 2: Page 36 (April 1998)

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Abstract: Two important developments in recent months have improved understanding of HIV-1 infection. First, several cell surface molecules have been discovered to be CD4 co-receptors, which are needed by HIV-1 to gain entry into cells. Attempting to prevent infection by blocking the principal co-receptors, as has been proposed, might simply allow other viral strains to emerge and eventually to dominate in an infected person. Second, reservoirs of replication-competent virus have been found in patients after two years or more of combination therapy. The absence of mutations associated with drug resistance during this length of time demonstrates the efficacy of current drug regimens, but the longevity of latently infected cells suggests that therapy must be continued indefinitely.

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