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Understanding drug-drug interactions

Phillip D. Hansten
From: Science & Medicine: Volume 5 Number 1: Page 16 (February 1998)

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Abstract: A generation ago, the number and varity of known interactions between drugs made them a natural choice for an early application of computerized data bases to clinical practice. Computer systems, although variable in quality and sometimes inconsistent, effectively replace human memory when the volume of information is so great. Expansion of the drug interaction knowledge base continues at a rapid rate, especially because of a recent focus on the detoxifying mechanisms of the cytochrome P450 family of mixed function enzymes. Though the details of drug interactions are complex, the underlying principles are straightforward and understandable.

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