Science & Medicine
Home | Current Issue | Archives | Subscriptions | Contact Us

Log In | Search | Author Index | Advertising

Selective inhibition of cyclooxygenase 2

Philip Needleman, Peter C. Isakson
From: Science & Medicine: Volume 5 Number 1: Page 26 (February 1998)

View Full TextAdd To BasketPurchase Images

Abstract: Gastric lesions and other, less common side effects limit long-term therapy with aspirin and other nnsteroidal anti-inflammitory agents. These drugs act by inhibiting the enzymatic action of cyclooxygenase, which is essential in the production of inflammatory mediators, particularly prostaglandins. The discovery that there are two cyclo-oxygenases, acttive in different tissues, has led to the identification of compounds that will selectively inhibit one enzyme or the other. COX-1 has physiologic functions, such as protecting the gastric mucosa and enabling platelet aggregation,, whereas COX-2 is the form involved in pathologic inflammatory processes.

Back to Table of Contents



Science & Medicine, Inc.
P.O. Box 313, Narberth, PA 19072
(610) 660-8097       (800) 888-0028
fax (610) 660-0348
e-mail editor@sciandmed.com
See our other journal: Medical Problems of Performing Artists.
Home | Current Issue | Archives | Subscriptions | Contact Us

Log In | Search | Author Index | Advertising

Copyright © 2002-2019, Science & Medicine, Inc.

Powered by Pliner Solutions, Inc.
Web Development by Pliner Solutions, Inc.